The Philippine Daily Inquirer's October 1, 2012 article Santo Domingo Church, La Naval de Manila shrine to be declared National Cultural Treasure summarizes the artistic treasures to be found in this great church:
Showcase of great architecture, great art
Measuring 85 meters in length, 40 meters in width and 25 meters in height, with a total floor area of 3,300 sq m, Santo Domingo Church is the biggest in Metro Manila and one of the biggest churches in Asia.
The massive church is a unique blend of Spanish colonial and modern architecture.
It was designed by José Ma. Zaragoza, who was still a student of architecture at UST when the Dominicans commissioned him to design the church.
Unlike the huge Baroque churches of the Hispanic period, the Santo Domingo is modern. But it follows the Mission-style architecture—with shades of Romanesque and Gothic designs—which welcomes more space.
Aside from being an architectural jewel, the Santo Domingo Church houses artistic treasures.
In the nave are eight colorful murals by National Artist Carlos “Botong” Francisco depicting the life and times of Santo Domingo de Guzman, the Spaniard who founded the Order of Preachers, whose members are now called Dominicans. Legend has it that it is to Saint Dominic that Our Lady gave the Rosary for the Dominicans to promote.
Francisco’s murals are just below the equally brilliant murals of the Four Evangelists in vivid brown tones by Vicente Garcia Llamas.
